MELBOURNE (AFP) – Both Bangladeshi twins whose conjoined heads and brains were separated this week are expected to make a full recovery, Australian doctors said on Thursday.

"Long-term, after seeing the scans I think they will be fine. It's all looking really good," neurosurgeon Wirginia Maixner told reporters.

The doctors were speaking after one of the two-year-old girls, Trishna, awoke from an induced coma and cuddled her guardian just two days after the marathon operation.

Her sister, Krishna, is expected to recover more slowly and will be woken up later as doctors withdraw sedatives.

Chief of surgery Leo Donnan was also upbeat after seeing scans of the girls' brains, which were prised apart after 32 hours of painstaking surgery.

"The scans look great. I believe we have brought them through safely," Donnan said. "I believe the girls will come out really, really good."

The comments cap an amazing story which has seen the ailing twins rescued from a Dhaka orphanage two years ago before being nursed back to health in Australia.

Specialist surgeons worked through the night on Monday to separate the girls' skulls, brains and blood vessels before reconstructive experts closed up their heads to prevent infection.