Who's Mad: Johnny Depp's latest 3D spectacular, 'Alice in Wonderland,' directed by Tim Burton, makes a killing at the box office.

“Avatar” is pretty smug in its position as the current holder of the ‘biggest grossing movie’ title and its impressive standing among 2010’s Oscar movie bets. But Tim Burton and Johnny Depp’s “Alice in Wonderland” sneaks up from behind to earn the distinction of becoming Hollywood’s first $100 million-plus movie earner to open outside the summer and holiday seasons.

Just like “Avatar,” “Alice in Wonderland” is also a 3D extravaganza that has also blown away big expectations, much to the delight of its studio and, by extension, the movie-making industry as well.

Proving yet again Johnny Depp’s amazing box office draw, “Alice In Wonderland” has earned an estimated $116.3 million during its weekend debut. The fact that it did so outside the traditional summer and holiday seasons, when most films really make a killing, is a feat in itself.

For now, here are the numbers from various reports online:

“Alice in Wonderland” has an opening weekend take of $116.3 million domestically (US and Canada). Worldwide it has by now reportedly made roughly $210.3 million overall—making it the biggest 3D debut in the books.

[Varying reports for “Avatar” put its domestic haul at only roughly between $77-$80 million on its opening weekend; worldwide, however, it still reigns supreme with an estimated total of $242 million.]

This record puts “Alice…” as the biggest non-sequel ever to open, beating the $114 million US/Canada opening of “Spider-man” in 2002.

It is now the second-biggest non-summer opening of all time behind the $142 million U.S. debut of “Twilight Saga: New Moon.”

The movie is Burton’s biggest in his directorial career riddled with big movies. His highest opening weekend prior to this was at 2001 with $68.5 million for “Planet of the Apes.”

Johnny Depp also has had a stellar box office career in the past decade or so. “Alice in Wonderland” may have done really well with these figures, but Depp’s biggest opener is still 2006’s “Pirates of the Caribbean: Dead Man’s Chest” at $135.6 million.

The IMAX Company has reported that “Alice…” made $11.9 million from its theaters alone during its weekend screenings.

“Avatar” is already on its 12th week in the theaters but it has reportedly lost close to 300 theaters mostly to “Alice…”

People might not see Burton as a mainstream movie director, but he holds a pretty good record of domestic (U.S./Canada) openings outside the holy trinity of Steven Speilberg, George Lucas and James Cameron. Burton’s “Batman” had an opening take of $40.4 million. Three years later, his own “Batman Returns” had opening returns of $45.6; followed by $30 million for “Sleepy Hollow” in 1999. His “Charlie and the Chocolate Factory” opened with $56.1 million in 2005. Pretty good for a non-mainstream kind of guy!

Johnny Depp now holds all three of the Disney's biggest opening weekends, with “Pirates of the Caribbean: Dead Man's Chest” ($135.6 million), “Alice in Wonderland” ($116.3 million), and “Pirates of the Caribbean: At World's End” ($114.7 million).

“Alice…” opened in more than 40 foreign countries with the following reported top earnings: Britain ($16.8 million), Italy ($13.9 million), Russia ($12.3 million), Australia ($9.2 million) and South Korea ($4.9 million).

While Disney never reveals production budgets, it was reported that “Alice…” cost over $200 million to make.

(Source: E! News online; The Huffington Post; Reuters)